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Year : 2010  |  Volume : 2  |  Issue : 3  |  Page : 248-257

Human immunodeficiency virus and leishmaniasis


1 Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, USA
2 Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles; Department of Medicine, Divisions of Dermatology and Infectious Diseases, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA

Correspondence Address:
Noah Craft
Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles; Department of Medicine, Divisions of Dermatology and Infectious Diseases, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/0974-777X.68528

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The leishmaniases are a group of diseases transmitted to humans by the bite of a sandfly, caused by protozoan parasites of the genus Leishmania. Various Leishmania species infect humans, producing a spectrum of clinical manifestations. It is estimated that 350 million people are at risk, with a global yearly incidence of 1-1.5 million for cutaneous and 500,000 for visceral leishmaniasis (VL). VL is a major cause of morbidity and mortality in East Africa, Brazil and the Indian subcontinent. Co-infection with human immunodeficiency virus (HIV) alters the immune response to the disease. Here we review the immune response to Leishmania in the setting of HIV co-infection. Improved understanding of the immunology involved in co-infections may help in designing prophylactic and therapeutic strategies against leishmaniasis.


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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008