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CASE REPORT Table of Contents   
Year : 2010  |  Volume : 2  |  Issue : 3  |  Page : 305-306
Kikuchi-Fujimoto disease from eastern India

1 Department of Medicine, Medical College and Hospitals, Kolkata, India
2 Eko CT and MRI Scan Center, Medical College and Hospitals Campus, Kolkata, India

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Date of Web Publication17-Aug-2010


Kikuchi's disease, a rare disorder which usually presents with fever painful lymphadenopathy, rash and arthritis, all of which are close mimickers of infective and immunological disorders. It is essentially a histopathological diagnosis and tests to rule out other connective tissue disorders or infective etiology must be undertaken. We present a series of two cases of kikuchi-fujimoto's disease presenting primarily with lymphadenopathy and fever in all cases. The first is a case of generalized lymphadenopathy and the second case of kikuchi's disease with SLE, a rare association. Lymph node excision biopsy and histopathology documented Kikuchi Fujimoto disease in above cases. All the cases improved on follow up and had no residual stigmata.

Keywords: Arthritis, Histiocytic necrotising lymphadenitis, Systemic lupus erythematosus (SLE)

How to cite this article:
Singhania P, Paul R, Maitra S, Banerjee A K, Hashmi M A. Kikuchi-Fujimoto disease from eastern India. J Global Infect Dis 2010;2:305-6

How to cite this URL:
Singhania P, Paul R, Maitra S, Banerjee A K, Hashmi M A. Kikuchi-Fujimoto disease from eastern India. J Global Infect Dis [serial online] 2010 [cited 2022 Nov 30];2:305-6. Available from:

   Case Report Top

A 32-year-old man presented with tender, discrete, soft, mobile lymph nodes in both axillae and right cervical region of one-month duration, with occasional fever. The lymph node histopathology showed pictures of  Kikuchi-Fujimoto disease More Details. At follow-up his lymph nodes had regressed significantly on symptomatic medicines.

Second case was that of a 55-year-old housewife who presented with high fever, polyarthritis, anasarca and oral ulcers [Figure 1]. There was nontender mobile lymphadenopathy in cervical, axillary and inguinal regions. USG abdomen revealed enlarged echogenic kidneys. ANF was positive (1:640; homogeneous); anti dsDNA= neg; 24-hour urinary protein was 7 g. Kidney biopsy showed features of lupus nephritis, WHO stage 2. A biopsy from axillary lymph node showed Kikuchi's disease [Figure 2]. The patient was given oral steroids with anti-rheumatic drugs for SLE. By three months, her lymph nodes regressed.
Figure 1 :Oral ulcer in case 2

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Figure 2 :Typical lymph node biopsy showing Histiocytes and macrophages

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   Discussion Top

Kikuchi's disease, histiocytic necrotising lymphadenitis, is a rare self-limiting disorder with fever, painful lymphadenopathy, rash and arthritis. [1] It is a histopathological diagnosis, and other infective and immunological disorders must be ruled out. [2] Both viral and immunologic etiologies are postulated. [3] The cardinal features are fever, painful cervical lymphadenopathy, rash or arthritis. The diagnosis is made by lymph node histopathology, which shows: para-cortical necrosis, histiocytes (crescentic nuclei) and karyorrhexis [Figure 1] and [Figure 3]. [4]
Figure 3 :Lymphnode histopathology show paracortical necrosis, Histiocytes (crescentic nuclei) & Karyorrhexis

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There are few reports of overlap of Kikuchi's disease, adult Stills disease, SLE and arthritis. [5],[6],[7],[8] Whether SLE has any causative role is not known. [9],[10],[11],[12] However, a distinct entity of necrotizing lymphadenitis in SLE mimicking Kikuchi's disease but responding to steroids and immunomodulators has been proposed. [13],[14] Kikuchi's disease is usually reported in young population and rarely over 50 years of age, [10] like our case.

   Conclusion and Teaching Points Top

Kikuchi's disease can present like infective lymphadenopathy and should be one of the differential diagnoses of enlarged lymph nodes. Histological examination is very important to distinguish it and avoid unnecessary treatment. Lymph nodes regress completely on symptomatic medicines without any residual stigma.

   References Top

1.Bennie MJ, Bowles KM, Rankin SC. Necrotizing cervical lymphadenopathy caused by Kikuchi-Fujimoto disease. Br J Radiol 2003;76:656-8.  Back to cited text no. 1  [PUBMED]  [FULLTEXT]  
2.Famularo G, Giustiniani MC, Marasco A, Minisola G, Nicotra GC, De Simone C. Kikuchi-Fujimoto lymphadenitis: Case report and literature review. Am J Haematol 2003;74:60-3.   Back to cited text no. 2      
3.Fujimoto Y, Kozima Y, Yamaguchi K. Cervical subacute necrotizing lymphadenitis. A new clinicopathological agent. Naika 1972;20:920-7.  Back to cited text no. 3      
4.Ifeacho S, Aung T, Akinsola M. Kikuchi-Fujimoto disease: A case report and review of the literature. Cases J 2008;1:187.  Back to cited text no. 4  [PUBMED]    
5.Ramanan AV, Wynn RF, Kelsey A, Baildam EM. Systemic juvenile idiopathic arthritis, Kikuchi's disease and haemophagocytic lymphohistiocytosis-is there a link? Case report and literature review. Rheumatology (Oxford) 2003;42:596-8.  Back to cited text no. 5  [PUBMED]  [FULLTEXT]  
6.Ohta A, Matsumoto Y, Ohta T, Kaneoka H, Yamaguchi M. Still's disease associated with necrotizing lymphadenitis (Kikuchi's disease): Report of 3 cases. J Rheumatol 1988;15:981-3.   Back to cited text no. 6  [PUBMED]    
7.Cousin F, Grezard P, Roth B, Balme B, Gregoire-Bardel M, Perrot H. Kikuchi disease associated with Still disease. Int J Dermatol 1999;38:464-7.  Back to cited text no. 7      
8.Douglas M, Bradbury R, Kannangara S, Mitchell D. Arthritis as an unusual manifestation of Kikuchi-Fujimoto disease. Rheumatology (Oxford) 2003;42:1010-2.  Back to cited text no. 8  [PUBMED]  [FULLTEXT]  
9.Bachi R. Kikuchi disease in a connective tissue disorder. Med J Malaysia 2002;57:357-60.   Back to cited text no. 9  [PUBMED]    
10.Mahmood A, Mir R, Salama SR, Miarrostami RM, Lapidus C, Pujol F. Kikuchi's disease: An unusual presentation and a therapeutic challenge. Yale J Biol Med 2006;79:27-33.   Back to cited text no. 10  [PUBMED]  [FULLTEXT]  
11.Tumiati B, Bellelli A, Portioli I, Prandi S. Kikuchi's disease in systemic lupus erythematosus: An independent or dependent event? Clin Rheumatol.1991;10:90-3.  Back to cited text no. 11      
12.Meyer O, Kahn MF, Grossin M, Ribard P, Belmatoug N, Morinet F, et al. Parvovirus B19 infection can induce histiocytic necrotizing lymphadenitis (Kikuchi's disease) associated with systemic lupus erythematosus. Lupus 1991;1:37-41.   Back to cited text no. 12  [PUBMED]    
13.Litwin MD, Kirkham B, Henderson DR, Milazzo SC. Histiocytic necrotising lymphadenitis in systemic lupus erythematosus. Ann Rheum Dis 1992;51:805-7.  Back to cited text no. 13  [PUBMED]  [FULLTEXT]  
14.Vilα LM, Mayor AM, Silvestrini IE. Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi's disease. Lupus 2001;10:126-8.  Back to cited text no. 14      

Correspondence Address:
M A Hashmi
Eko CT and MRI Scan Center, Medical College and Hospitals Campus, Kolkata
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-777X.68539

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
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