Journal of Global Infectious DiseasesOfficial Publishing of INDUSEM and OPUS 12 Foundation, Inc. Users online:531  
Print this pageEmail this pageSmall font sizeDefault font sizeIncrease font size     
Home About us Editors Ahead of Print Current Issue Archives Search Instructions Subscribe Advertise Login 

   Table of Contents     
Year : 2011  |  Volume : 3  |  Issue : 3  |  Page : 312-313
Polymicrobial sepsis in an immunocompetent host due to self injection of urine

1 Sri Gokulam Hospitals and Research Institute, Salem, TamilNadu, India
2 Chennai Medical College and Research Center, Irungalur, Trichy, India

Click here for correspondence address and email

Date of Web Publication6-Aug-2011

How to cite this article:
Senthilkumaran S, Sweni S, Balamurugan N, Thirumalaikolundusubramanian P. Polymicrobial sepsis in an immunocompetent host due to self injection of urine. J Global Infect Dis 2011;3:312-3

How to cite this URL:
Senthilkumaran S, Sweni S, Balamurugan N, Thirumalaikolundusubramanian P. Polymicrobial sepsis in an immunocompetent host due to self injection of urine. J Global Infect Dis [serial online] 2011 [cited 2022 Nov 27];3:312-3. Available from:


Auto urine therapy (AUT) is practiced worldwide either as prophylaxis or as a therapy in complementary and alternative medicine [1] for many diseases. Though many cases of AUT are known, urine-induced sepsis is not reported yet to our knowledge. Herein, a case of near fatal polymicrobial sepsis with acute respiratory distress syndrome due to self injection of urine is reported for its rarity and to create awareness among physicians working in emergency care.

A 38-year-old livestock inspector was brought to the emergency room (ER) in an unconscious state following two episodes of a witnessed new-onset generalized tonic-clonic seizure (GTCS) within a period of 30 minutes. There was a history of fever associated with chills and rigors since 12 hours. The patient had no previous history of seizures, head injuries, or any other illnesses and was not on any regular medications or illicit drugs. Family history was not contributory.

On admission, he was unconscious with a Glasgow coma scale (GCS) of 8/15 and the pupils were 4 mm dilated and sluggishly reacting to light. There were no meningeal signs or rashes. He was febrile (104 F) and had frothy blood stained secretion in the oropharynx. He was tachycardic (pulse 128/minute) with supine BP 90/60 mmHg, SaO 2 80%, and FiO 2 0.9. He had shallow respiration (rate 11/minute) with bilateral coarse rales extending up to apices of both lungs. The rest of the clinical examination was unremarkable.

Arterial blood gas (ABG) revealed wide anion gap with metabolic acidosis and hypoxia. The total WBC was 36.0×10 3 /mm 3 with 41% band forms and neutrophils 25.4×10 3 /mm 3 . Hemoglobin, packed cell volume (PCV), platelet count, electrolytes, liver function test, coagulation profile, capillary blood sugar and CSF were normal. His HIV status and peripheral smear for malaria were negative. Blood and urine were negative for toxicology or for any drugs. His ultrasound abdomen, CT brain, and ECG were unremarkable. The chest X-ray showed extensive bilateral alveolointerstitial infiltrate compatible with acute respiratory distress syndrome (ARDS). He was started on anticonvulsants and intravenous broad-spectrum antibiotics in Intensive care unit (ICU). Inotropic support was started to maintain blood pressure. He was stabilized in the following 48 hours. His blood cultures grew K.pneumoniae, E. coli, and Proteus, which were sensitive to imipenem. Antibiotics were changed as per culture and sensitivity pattern. The sepsis started subsiding gradually and patient got discharged on day 12.

On day 11, he confessed that he collected his urine in a container and self injected about 10 ml of his urine intravenously to maximize his vitality and potency, as he had developed nausea and vomiting twice after drinking his urine orally. This might have led to polymicrobial sepsis, toxic encephalopathy, and septic shock with multi organ dysfunction. Psychological assessment did not reveal any abnormalities.

Drinking one's own urine in the morning ("amaroli") is a traditional practice in yoga as well as "Siddha medicine" a branch of complementary and alternative medicine taught officially at some Indian medical universities. [2] It recommends drinking one's own urine for prophylactic and therapeutic purposes. Oral urea and methylglyoxal, both derivatives of urine have anticancer properties. [3],[4]

Although urine therapy might have its own benefits, its practitioners and followers should exhibit caution. Also, when a clinician is confronted with challenges of polymicrobial infection, in an immunocompetent individual, history of an unconventional cause either deliberate (Munchausen's) or as unconventional methods needs to be elicited.

   References Top

1.The miracles of urine therapy. Life Positive(June). Available from:[Last cited on 2011, Feb 13].  Back to cited text no. 1
2.Mills MH, Faunce TA. Melatonin supplementation from early morning auto-urine drinking. Medical Hypotheses 1991;36:195-9.  Back to cited text no. 2
3.Danopoulos E, Danopoulou I. Letter: Regression of liver cancer with oral urea. Lancet 1974;1:132.  Back to cited text no. 3
4.Talukdar D, Chaudhuri BS, Ray M, Ray S. Critical evaluation of toxic versus beneficial effects of methylglyoxal. Biochemistry 2009;74:1059-69.  Back to cited text no. 4

Correspondence Address:
Subramanian Senthilkumaran
Sri Gokulam Hospitals and Research Institute, Salem, TamilNadu
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/0974-777X.83545

Rights and Permissions


    Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
    Email Alert *
    Add to My List *
* Registration required (free)  


 Article Access Statistics
    PDF Downloaded33    
    Comments [Add]    

Recommend this journal

Sitemap | What's New | Feedback | Copyright and Disclaimer | Privacy Notice | Contact Us
2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008