| ORIGINAL ARTICLE |
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| Year : 2018 | Volume
: 10
| Issue : 4 | Page : 206-211 |
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Action of colloidal bismuth hydroxide gel and its commercial cream on enteropathogens and colonizers of the gastrointestinal tract
Tomás Subils, Cecilia Casabonne, Agustina González, Virginia Aquili, Claudia E Balagué
Department of Microbiology, Faculty of Biochemical and Pharmaceutical Sciences, National University of Rosario, Suipacha, Rosario, Santa Fe, Argentina
Correspondence Address:
Dr. Tomás Subils
Suipacha 531 S2002lRK, Rosario, Santa Fe
Argentina
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jgid.jgid_102_17
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Background: Acute diarrheal diseases constitute a world public health problem because they are the second cause of death in children under 5 years of age. Colloidal bismuth hydroxide gel (CBHG) is an active ingredient in low-cost, antidiarrhetic drugs for oral use; it does not inhibit intestinal motility, and it features very low intestinal absorption of <1%. Materials and Methods: We analyzed the sensitivity by determining the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC); the effect on bacterial growth by studying the specific growth velocity and the generation time in growth curves; and bacterial attachment by counting viable plaques, of enteropathogenic Escherichia coli, shigatoxigenic E. coli O157:H7, Klebsiella pneumoniae, Salmonella spp., and Shigella flexneri in the commercial cream (Chobet® bismuth cream with pectin [CBCHP]), its active ingredient (CBHG), and its excipients (E) separately. Results: CBCHP: MIC 6–10 mg/ml and MBC 7.5–15 mg/ml of bismuth; CBHG: MIC 6–10 mg/ml of bismuth. E: No inhibition was observed at the concentration studied in this study. At very low subinhibitory concentrations of CBCHP and CBHG, there was already evidence of a significant decrease in growth, which could not be recorded for E. CBCHP and CBHG presented an elevated capacity for bacterial displacement, significantly greater than E. Conclusions: We believed that the results obtained in this study are very promising from the treatment standpoint, as a possible treatment for cases of diagnosis or suspicion of bacterial gastroenteritis. The antimicrobial and attachment effects of CBCHP are exclusively due to its active ingredient CBHG; these effects are promoted in the presence of E.
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