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MICROBIOLOGY REPORT
Year : 2020  |  Volume : 12  |  Issue : 4  |  Page : 214-216

Hepatitis E virus infection among asymptomatic pregnant women at the University College Hospital, Ibadan


1 Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, Oyo, Nigeria
2 Department of Medical Microbiology and Parasitology, College of Health Sciences, University of Abuja, Abuja, Nigeria
3 Department of Obstetrics and Gynaecology College of Medicine, University of Ibadan, Oyo, Nigeria

Correspondence Address:
Adeola Fowotade
Clinical Virology Unit, Department of Medical Microbiology, College of Medicine, University of Ibadan
Nigeria
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jgid.jgid_124_19

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Introduction: The high mortality associated with fulminant Hepatitis E infection in pregnancy justifies the need to assess the epidemiologic proportion of this underestimated virus. Objectives: This study aimed to determine the burden of HEV infection among pregnant women attending antenatal Clinic in Ibadan. Methodology: HEV IgG and IgM serological surveys were carried out among 230 pregnant women attending antenatal clinic in Ibadan, Nigeria. Serum and stool samples from HEV IgM positive women were further analysed using two independent reverse transcriptase polymerase chain reactions (RT-PCR) assays, targeting ORF1 region of HEV genome. Socio-demographic variables associated with HEV in these women, were analyzed to estimate statistical significance (p < 0.05). Results: Eleven (4.8%) women had HEV IgM, while 39 (17.0%) women had HEV IgG. Three (27.3%) of the 11 anti-HEV IgM positive samples were positive for HEV RNA while all stool samples tested negative for HEV RNA. HEV infection among pregnant women was statistically associated with age (p = 0.044), and educational status (p = 0.005). Conclusion: Recent HEV infection among this pregnant population is on the lower part of the scale, compared with other Sub-Saharan African countries. However, the HEV IgG seroprevalence rate suggests indirect evidence of past contact with HEV.


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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008