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Year : 2021  |  Volume : 13  |  Issue : 1  |  Page : 56-58

Idiopathic CD4 lymphocytopenia presenting as cryptococcal meningitis

1 Department of Endocrinology and Diabetes, Pinderfields General Hospital, Wakefield, United Kingdom
2 Department of General Medicine, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
3 Department of Critical Care, Jaslok Hospital and Research Centre, Mumbai, Maharashtra, India
4 Department of General Surgery, Lokmanya Tilak Municipal Medical College and Hospital, Mumbai, Maharashtra, India

Correspondence Address:
Dr. Ankita Prashant Hingolikar
Department of General Medicine, Jaslok Hospital and Research Centre, Mumbai - 400 026, Maharashtra, India
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jgid.jgid_182_20

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A 54-year-old male presented to our center with a 3-month history of headache, giddiness, and blurring of vision. Cerebrospinal fluid examination revealed him to be having cryptococcal meningitis. He was worked up for probable causes of immunosuppression including HIV and other infections and had an autoimmune profile as well as a bone marrow examination, none of which revealed any abnormality. Lymphocyte flow cytometry revealed low counts of CD4 T lymphocytes, likely secondary to idiopathic CD4 lymphocytopenia. He was treated for cryptococcal meningitis. Due to marked immunosuppression, the disease progressed rapidly with deterioration in neurological and hemodynamic status, leading to his demise.

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2008 Journal of Global Infectious Diseases | Published by Wolters Kluwer - Medknow
Online since 10th December, 2008