| CASE REPORT |
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| Year : 2022 | Volume
: 14
| Issue : 4 | Page : 165-169 |
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Capsule-deficient cryptococcal meningitis: A diagnostic conundrum
Trupti Shende1, Gagandeep Singh1, Immaculata Xess1, Swati Khullar1, Renu Kumari Yadav1, Reshu Agarwal1, M Vasantha Padma Srivastava2
1 Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
2 Department of Neurology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India
Correspondence Address:
Dr. Gagandeep Singh
Department of Microbiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi - 110 029
India
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/jgid.jgid_255_21
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Cryptococcosis is a serious systemic mycosis. Its incidence has escalated in the past four decades. Cryptococcus neoformans causes localized or disseminated infection in immunocompromised and immunocompetent patients. The capsulated form is commonly encountered which can be diagnosed on an India ink preparation or antigen detection. However, the noncapsulated forms are very rare and require a high index of suspicion for correct diagnosis. Herein, we present a case of cryptococcal meningitis due to a noncapsulated strain in an apparently immunocompetent patient with no proven immunodeficiencies along with review of world literature. Such cases are a diagnostic challenge for the clinician as well as microbiologist.
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