Journal of Global Infectious Diseases

UPDATE ARTICLE
Year
: 2010  |  Volume : 2  |  Issue : 3  |  Page : 248--257

Human immunodeficiency virus and leishmaniasis


Navid Ezra1, Maria Teresa Ochoa1, Noah Craft2 
1 Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles, USA
2 Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles; Department of Medicine, Divisions of Dermatology and Infectious Diseases, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA, USA

Correspondence Address:
Noah Craft
Department of Medicine, Division of Dermatology, David Geffen School of Medicine at UCLA, Los Angeles; Department of Medicine, Divisions of Dermatology and Infectious Diseases, Harbor-UCLA Medical Center and Los Angeles Biomedical Research Institute, Torrance, CA
USA

The leishmaniases are a group of diseases transmitted to humans by the bite of a sandfly, caused by protozoan parasites of the genus Leishmania. Various Leishmania species infect humans, producing a spectrum of clinical manifestations. It is estimated that 350 million people are at risk, with a global yearly incidence of 1-1.5 million for cutaneous and 500,000 for visceral leishmaniasis (VL). VL is a major cause of morbidity and mortality in East Africa, Brazil and the Indian subcontinent. Co-infection with human immunodeficiency virus (HIV) alters the immune response to the disease. Here we review the immune response to Leishmania in the setting of HIV co-infection. Improved understanding of the immunology involved in co-infections may help in designing prophylactic and therapeutic strategies against leishmaniasis.


How to cite this article:
Ezra N, Ochoa MT, Craft N. Human immunodeficiency virus and leishmaniasis.J Global Infect Dis 2010;2:248-257


How to cite this URL:
Ezra N, Ochoa MT, Craft N. Human immunodeficiency virus and leishmaniasis. J Global Infect Dis [serial online] 2010 [cited 2022 Jul 4 ];2:248-257
Available from: https://www.jgid.org/article.asp?issn=0974-777X;year=2010;volume=2;issue=3;spage=248;epage=257;aulast=Ezra;type=0