Journal of Global Infectious Diseases

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 13  |  Issue : 2  |  Page : 67--71

Incidence of secondary bacterial infections following utilization of tocilizumab for the treatment of COVID-19 – A matched retrospective cohort study


Joanna L Moore1, Stephanie J Stroever2, Patricia E Rondain1, Robyn N Scatena3 
1 Department of Medicine, Nuvance Health, University of Vermont School of Medicine, Norwalk, Connecticut, USA
2 Department of Innovation and Research, Nuvance Health, Danbury, Connecticut, USA
3 Department of Pulmonary and Critical Care, Yale School of Medicine, University of Vermont School of Medicine, Nuvance Health, Norwalk, Connecticut, USA

Correspondence Address:
Dr. Joanna L Moore
34 Maple Street, Norwalk, Connecticut 06850
USA

Introduction: Immunosuppressive agents are theorized to target the cytokine storm syndrome in COVID-19. However, the downstream effects regarding susceptibilities to secondary infection risk remains unknown. This study seeks to determine risk differences for secondary infections among COVID-19 patients who did and did not receive tocilizumab. Methods: We conducted a matched retrospective cohort study from two large, acute care hospitals in Western Connecticut from March 1, to May 31, 2020. We collected variables using manual medical record abstraction. The primary exposure variable was any dose of tocilizumab. The primary outcome was any healthcare-associated bacterial or fungal infection as defined by the National Healthcare Safety Network. We performed a Kaplan–Meier analysis to assess the crude difference in cumulative probability of healthcare-associated infection (HAI) across exposure groups. We also performed a multivariable Cox regression analysis to determine the hazard ratio for HAI by exposure group while controlling for potential confounders. Results: The Kaplan–Meier analysis demonstrated no difference in the cumulative probability of HAI across groups. The adjusted hazard of HAI for patients given tocilizumab was 0.85 times that of patients not given tocilizumab (95% confidence interval = 0.29, 2.52, P = 0.780) after controlling for relevant confounders. Conclusions: Tocilizumab did not increase the incidence of secondary infection among COVID-19 patients. Larger, randomized trials should evaluate infection as a secondary outcome to validate this finding.


How to cite this article:
Moore JL, Stroever SJ, Rondain PE, Scatena RN. Incidence of secondary bacterial infections following utilization of tocilizumab for the treatment of COVID-19 – A matched retrospective cohort study.J Global Infect Dis 2021;13:67-71


How to cite this URL:
Moore JL, Stroever SJ, Rondain PE, Scatena RN. Incidence of secondary bacterial infections following utilization of tocilizumab for the treatment of COVID-19 – A matched retrospective cohort study. J Global Infect Dis [serial online] 2021 [cited 2021 Jun 19 ];13:67-71
Available from: https://www.jgid.org/article.asp?issn=0974-777X;year=2021;volume=13;issue=2;spage=67;epage=71;aulast=Moore;type=0