Journal of Global Infectious Diseases

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 14  |  Issue : 2  |  Page : 64--68

Hyponatremia in melioidosis: Analysis of 10-year data from a hospital-based registry


Indu Ramachandra Rao1, Tushar Shaw2, Ravindra Attur Prabhu1, Vandana Kalwaje Eshwara2, Shankar Prasad Nagaraju1, Dharshan Rangaswamy1, Srinivas Vinayak Shenoy1, Mohan Varadanayakanahalli Bhojaraja1, Chiranjay Mukhopadhyay3 
1 Department of Nephrology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
2 Department of Microbiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India
3 Department of Microbiology, Kasturba Medical College Manipal, Manipal Academy of Higher Education; Center for Emerging and Tropical Diseases, Manipal Academy of Higher Education, Manipal, Karnataka, India

Correspondence Address:
Dr. Ravindra Attur Prabhu
Department of Nephrology, Kasturba Medical College, Tiger Circle Road, Madhav Nagar, Manipal - 576 104, Udupi District, Karnataka
India

Introduction: Hyponatremia is a frequent finding in hospitalized patients and is associated with poor clinical outcomes. While hyponatremia is known to commonly occur in certain infections, its association with melioidosis has not been studied previously. We studied incidence and impact of hyponatremia on clinical outcomes in melioidosis. Methods: This was a retrospective analysis of a single-center hospital registry of culture-positive patients with melioidosis hospitalized during a 10-year period (January 01, 2010, through January 31, 2021). Hyponatremia was defined as serum sodium of <135 mmol/L, and severe hyponatremia as serum sodium <120 mmol/L. The association of hyponatremia with in-hospital mortality, need for intensive care unit (ICU) stay and mechanical ventilation was studied. Results: Of 201 patients with melioidosis, 169 (84.1%) had hyponatremia, with severe hyponatremia in 35 (17.4%) patients. Older age (adjusted odds ratios [OR] 1.03, 95% confidence intervals [CI]: 1.00–1.06; P = 0.049) and acute kidney injury (AKI) (adjusted OR 3.30, 95% CI: 1.19-9.19; P = 0.02) were independently associated with hyponatremia. Twenty-two patients had been evaluated for cause of hyponatremia and of these, 11 (50%) had syndrome of inappropriate antidiuresis. Severe hyponatremia was associated with in-hospital mortality (adjusted OR 3.75, 95% CI: 1.37–10.27; P = 0.01), need for ICU stay (adjusted OR 7.04, 95% CI: 2.88–17.19; P < 0.001) and mechanical ventilation (adjusted OR 3.99, 95% CI: 1.54–10.32; P = 0.004). Conclusion: Hyponatremia occurs in 84.1% of hospitalized patients with melioidosis. Older age and AKI are associated with a higher incidence of hyponatremia. The presence of severe hyponatremia is an independent predictor of in-hospital mortality, need for mechanical ventilation and ICU stay.


How to cite this article:
Rao IR, Shaw T, Prabhu RA, Eshwara VK, Nagaraju SP, Rangaswamy D, Shenoy SV, Bhojaraja MV, Mukhopadhyay C. Hyponatremia in melioidosis: Analysis of 10-year data from a hospital-based registry.J Global Infect Dis 2022;14:64-68


How to cite this URL:
Rao IR, Shaw T, Prabhu RA, Eshwara VK, Nagaraju SP, Rangaswamy D, Shenoy SV, Bhojaraja MV, Mukhopadhyay C. Hyponatremia in melioidosis: Analysis of 10-year data from a hospital-based registry. J Global Infect Dis [serial online] 2022 [cited 2023 Feb 3 ];14:64-68
Available from: https://www.jgid.org/article.asp?issn=0974-777X;year=2022;volume=14;issue=2;spage=64;epage=68;aulast=Rao;type=0